Nonsteroidal Anti-Inflammatory Drug-Induced Colopathy in a Colorectal Cancer Screening Program
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چکیده
منابع مشابه
Nonsteroidal anti-inflammatory drug (NSAID)-induced colopathy with diaphragm-like strictures.
A 79-year-old female patient with coxarthrosis and gonarthrosis had been taking Diclofenac for 10 years. She reported asthenia, abdominal pain in the le upper quadrant and two self-limited episodes of hematochezia in the ve previous months. She had microcytic, hypochromic, sideropenic anemia (hemoglobin: 9.0 g/dL) in spite of several previous packed red blood cells transfusions. Upper endoscopy...
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Nonsteroidal anti-inflammatory drug (NSAID) colitis is a clinically significant disease, which may present with diarrhea, anemia, and nonspecific abdominal complaints. The definition of NSAID colitis is: endoscopy changes (not necessarily with formed diaphragm, capsule endoscopy not obligatory) plus history of taking NSAID on a regular basis or on demand basis plus clinical symptoms (sideropeni...
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Cyclooxygenase-2 (COX-2) is an important pharmacological target with great promise in the prevention and treatment of colorectal cancer (CRC). The mechanism underlying COX-2 overexpression in CRC is unresolved. On the basis of the coincident high levels of the transcription factor c-MYB and COX-2 in CRC, we hypothesized that c-MYB is a candidate activator of COX-2 transcription. We identified 1...
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BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to act via induction of apoptosis-programmed cell death-as potential colorectal cancer chemopreventive agents. NSAIDs can alter the production of different metabolites of polyunsaturated fatty acids (linoleic and arachidonic acids) through effects on lipoxygenases (LOXs) and cyclooxygenases. 15-LOX-1 is the main enzyme for metaboli...
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Several epidemiological studies have identified an association between nonsteroidal anti-inflammatory drug (NSAID) use and colorectal cancer risk in women. We examined this association in a population-based case-control study in Wisconsin women. Between 1991 and 1992, 184 women ages 40-74 years with colorectal cancer were identified through the statewide cancer registry and 293 population-based...
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ژورنال
عنوان ژورنال: Medical Principles and Practice
سال: 2018
ISSN: 1011-7571,1423-0151
DOI: 10.1159/000494839